Fluids and Catheters Treatment Trial (FACTT) compares the patients receiving PAC or a central venous catheter (CVC) with one of two fluid management strategies (conservative vs. liberal).
- multicenter trial is designed to include 1000 patients.
- The primary endpoint is mortality at 60 days. (no change)
- Secondary endpoints include ventilator free days and (with conservative fluid strategy decreased)
- organ failure free days.(no change)
adapting more conservative fluid management is better while treating ALI and ARDS patients.