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Thursday, December 18, 2008

Mannitol for acute traumatic brain injury. [Cochrane Database Syst Rev. 2005] - PubMed Result

Mannitol for acute traumatic brain injury


Mannitol for acute traumatic brain injury. [Cochrane Database Syst Rev. 2005] - PubMed Result: "CONCLUSIONS: High-dose mannitol may be preferable to conventional-dose mannitol in the acute management of comatose patients with severe head injury. Mannitol therapy for raised ICP may have a beneficial effect on mortality when compared to pentobarbital treatment, but may have a detrimental effect on mortality when compared to hypertonic saline. ICP-directed treatment shows a small beneficial effect compared to treatment directed by neurological signs and physiological indicators. There are insufficient data on the effectiveness of pre-hospital administration of mannitol."