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Thursday, August 27, 2009

Cardiac troponin T in acute coronary syndrome with...[Asian Cardiovasc Thorac Ann. 2008] - PubMed Result

Cardiac troponin T in acute coronary syndrome with...[Asian Cardiovasc Thorac Ann. 2008] - PubMed Result: "Cardiac troponin T in acute coronary syndrome with renal insufficiency.Chew HC.
Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Outram Road, Singapore. chinnjing@pacific.net.sg
Cardiac troponin levels are frequently elevated in patients with chronic renal failure, hence diagnosis of myocardial necrosis is difficult. The prevalence of elevated serum troponin T was determined and its diagnostic value in acute coronary syndrome was assessed in patients with chronic renal insufficiency. A retrospective cross-sectional analysis was performed in 227 patients with chronic renal insufficiency and a diagnosis of unstable angina, non-ST or ST-segment elevation myocardial infarction. All patients had baseline serum troponin T levels measured at previous visits; the baseline troponin T level was raised in 53.3%. Cardiac troponin T levels did not correlate with creatinine levels, and were not affected by dialysis. Mortality after an acute coronary event was high (46.3%). Because of the elevated baseline cardiac troponin T levels, detection of acute coronary syndrome in patients with chronic renal failure requires evaluation of serial cardiac enzyme measurements and serial 12-lead electrocardiograms. Early and definitive cardiac interventions may contribute towards decreasing the mortality rate in this group of patients."