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Sunday, September 13, 2009

Perioperative beta-blockade, 2008: What does POISE tell us, and was our earlier caution justified? -- Sear et al. 101 (2): 135 -- British Journal of Anaesthesia

Perioperative beta-blockade, 2008: What does POISE tell us, and was our earlier caution justified? -- Sear et al. 101 (2): 135 -- British Journal of Anaesthesia: "The POISE study highlights the increased risks of stroke and all-cause mortality associated with the perioperative administration of beta-blocking drugs. Other strategies need therefore to be examined as ways of providing cardiac protection. Perioperative beta-blockade should only be prescribed on an individual patient basis after due consideration has been given to their possible benefits and hazards."

POISE showed evidence of cardiac protection. This included a reduction of myocardial infarction.

POISE only studied the effects on outcome of acute perioperative beta-blockade

it is recommended that patients already on beta-blockers be maintained on their medication throughout the perioperative period